Adrafinil vs Modafinil

There are more than 200 nootropics on the market today. Adrafinil is a powerful stimulant that can produce a sense of euphoria and a feeling of being “high.” It has also been used by athletes to increase physical energy and stamina. Modafinil (Provigil), on the other hand, is a wakefulness-promoting agent. It enhances focus, concentration, memory and the ability to process information.

Modafinil and adrafinil are related compounds that have nearly identical effects, but they’re also distinct in a number of ways. Adrafinil was initially marketed as a sleep aid, whereas modafinil was originally developed as a treatment for narcolepsy.

Both compounds are powerful and potent stimulants that are highly effective for combating brain fog, cognitive decline, and fatigue.

What is Adrafinil?

Adrafinil is a medication developed in France that was discontinued in 2011. Initially, the medication was developed as a replacement for Provigil. Since then, the smart pill has been sold as a nootropic over-the-counter.

Adrafinil has a chemical structure that is comparable to Modafinil. There are, nevertheless, significant distinctions. The amide nitrogen of adrafinil has an extra OH (hydroxyl group). Hydroxylamine is formed as a result of this reaction.

The medication is then transformed to Modafinil once it is eaten. The physiologically active element in Adrafinil is modafinil.

The effects of Adrafinil are thus similar to modafinil, and they include:

  • Increased alertness
  • Increased focus and concentration
  • Fatigue

These effects, however, are rarely as powerful as Modafinil. In fact, most doctors now skip Adrafinil and go straight to Modafinil when prescribing wakefulness medications.

See also Modafinil vs Vyvanse: How They Stack Up

What is Modafinil?

What is Modafinil

Modafinil is a drug developed in France in the early 1990s that stimulates production of dopamine, a neurotransmitter that regulates brain functions related to motivation and pleasure. It was originally used by people who experienced fatigue due to a deficiency of this neurotransmitter, but it has since become popular among people interested in improving their memory and attention. The first-generation version of this substance, CRL-40,440, was the same as the more popular modafinil.

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Modafinil works by increasing the activity of brain centers that regulate wakefulness and attention, and has been shown to work effectively for the management of shift workers, excessive daytime sleepiness (in patients with obstructive sleep apnea and idiopathic hypersomnia), and excessive sleepiness from multiple sclerosis, depression, Parkinson’s disease, and other conditions.

Modafinil Vs Adrafinil: Benefits

Both adrafinil and modafinil are highly effective at promoting wakefulness, increasing alertness, inhibiting the desire to sleep, delaying the onset of fatigue, and reducing tiredness perception. Eugeroics have been proven to be more effective than methamphetamine at suppressing the need to sleep, resulting in longer periods of wakefulness without the excessive tiredness associated with other stimulants.

Adrafinil and modafinil have also been demonstrated to improve a variety of cognitive capacities, including working memory and fluid intelligence, as well as spatial and episodic memory, pattern recognition, executive function, and performance on tasks requiring higher-level thinking. Clinical investigations show that eugeroics boost mood in both sleep-deprived and non-fatigued people, and current research reveals that adrafinil/modafinil may have neuroprotective characteristics that help the brain function properly.

While adrafinil and modafinil are both safe, effective, and well-tolerated, long-term daily use is not advised.

Modafinil Vs Adrafinil: Side Effects

Modafinil Vs Adrafinil

You might be thinking that these two Nootropics are similar because they’re both classified as smart drugs, but it’s not that simple. One of them, Modafinil is the brand name of Armodafinil, while the other one, Adrafinil is also a brand name for Alprazolam, a benzodiazepine medication, with different indications than those of Modafinil.

Adrafinil and modafinil work the same way. They both increase acetylcholine levels and help improve mental focus, concentration and energy. The difference lies in how they are taken and the duration of effects. Adrafinil will usually take about an hour or two to kick in, but modafinil has a more immediate effect. Both can make it harder to fall asleep and may cause headaches, nausea and loss of appetite.

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Adrafinil has fewer reported side effects than Modafinil, though the two can have some of the same effects. Adrafinil is used to treat sleepiness, depression, and narcolepsy, while Modafinil is more commonly used to help people with ADD and ADHD stay alert, increase productivity, and enhance focus. The drug is generally safe for most people.

See also Sunosi vs Modafinil: How They Stack Up

Adrafinil Vs Modafinil: What Is Better?

The debate has been around for a very long time. What is the difference between modafinil and adrafinil? Both are powerful stimulants. They are chemically similar in that both contain the same chemical ingredients, yet are produced by different companies with slightly different names. Both are often described as “smart drugs”. You can find both drugs sold online in Canada. There have been cases of side effects reported for each, though not all users report these.

Adrafinil is an over-the-counter medication that can be found at any pharmacy. It’s sold as a sleep aid under the brand name Provigil and a wakefulness aid under the brand name Aremfor. The active ingredient in adrafinil is armodafinil (Nuvigil), a derivative of modafinil. Modafinil is approved by the FDA for use as a “smart drug.” 

Modafinil is a synthetic drug similar to amphetamines. It works by increasing the amount of dopamine in the brain. Some studies have shown Modafinil improves focus and increases wakefulness. Armodafinil is a derivative of Modafinil with fewer side effects and less potential to cause drowsiness.

For a healthy person, there’s little difference between modafinil and adrafinil. Both of these nootropics are safe and they can give you a good night’s sleep as well as wake you up. They also come in very effective doses for daytime use. Adrafinil also has a slightly lower dose than modafinil, which can help you avoid a common side effect that happens with modafinil when your body builds up a tolerance to it. So while the efficacy of each may be slightly different, they all have similar effects. They are designed to increase wakefulness, concentration, and motivation. They will allow you to focus longer without becoming distracted.


Modafinil Vs Adrafinil: Our Verdict

Modafinil Vs Adrafinil

We’ve discussed each drug above, but for those who want a simple rundown, well, the truth of the matter is that any of these nootropics will do, and the answer to which is best will depend on your individual needs.

In our opinion, however, Modafinil is far more effective and potent in general. 

Modafinil is better if you want to maximize your life and make the most of your smart drug day. 

However, if you’re new to nootropics and just want a few hours of strong focus every now and then, Adrafinil can help – without the negative side effects of Modafinil, which can keep you up at night if taken too late in the day.


The two nootropics that we’ve talked about in this article are Armodafinil and Modafinil. They are both great nootropic drugs that can help you stay awake, alert, and focused.

Modafinil is more commonly used to treat ADD and ADHD, and can also help you stay awake, alert, and focused. Adrafinil has fewer side effects than Modafinil, but they both have the potential to cause headaches, nausea, and loss of appetite. Modafinil is more effective than Adrafinil, but they both have the same duration of action. Both drugs are safe and effective for their intended use.

Both drugs can help you focus and stay awake, and are considered safe and effective. They can both be found in the same places, including online.

See also Armodafinil vs Modafinil: How Do They Stack Up?